Hemp extract & cHRONIC pain AND WELLNESS
The relationship between CBD and the human body is complex and requires further research to fully comprehend, but we already know a fair amount about this multi-faceted interaction.
CBD interacts with a wide range of proteins in the body and central nervous system, including components of the endocannabinoid system (ECS), including the CB1 receptors located in the brain and central nervous system and CB2 cannabinoid receptors located in the spleen and immune system. Unlike THC, which strongly binds to these two receptors, CBD is actually an inverse agonist that has the opposite effect. Instead,
CBD inhibits the absorption of anandamide, a natural cannabinoid molecule that regulates pain and correlates with feelings of well-being and happiness.
Past research has also found that CBD targets alpha-3 glycine receptors to suppress chronic pain and reduce inflammation associated with dysfunctional glycine receptors, which are an important target for pain processing in the spine.
CBD also activates other receptor proteins, such as the vanilloid receptor TRPV1, which is responsible for control functions such as inflammation and the awareness of pain. In the case of rheumatoid arthritis and other instances of disease-associated chronic pain, the sensitivity and expression of TRPV1 receptors increases.
A 2014 study published in the British Journal of Pharmacology found that the purported analgesic properties of CBD are mediated by this receptor, leading the research team to conclude that CBD could be a “useful pharmacological alternative in the treatment of the disease-associated chronic pain.”
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